Association of Intact dupA (dupA1) rather than dupA1 cluster with duodenal ulcer in Indian population
نویسندگان
چکیده
منابع مشابه
Association of Intact dupA (dupA1) rather than dupA1 cluster with duodenal ulcer in Indian population
BACKGROUND The duodenal ulcer promoting gene (dupA) and dupA cluster in Helicobacter pylori have been described as a risk factor for duodenal ulcer development in some populations. Polymorphic gene dupA can be divided into two groups, intact dupA1 (long or short type based on the presence or absence of 615-bp extra sequences at the 5' region) having complete reading frame and other truncated du...
متن کاملSignificant association of dupA of Helicobacter pylori with duodenal ulcer development 5 in South East Indian Population
1 No. JMM/2011/038398 2 3 4 Significant association of dupA of Helicobacter pylori with duodenal ulcer development 5 in South East Indian Population 6 7 8 Jawed Alam 1 , Sankar Maiti 2 , Prachetash Ghosh 1 , Ronita De 1 , Abhijit Chowdhury 3 , 9 Suryasnata Das 4 , Ragini Macaden 4 , Harshad Devarbhavi 4 , T. Ramamurthy 1 , and Asish 10 K. Mukhopadhyay 1 * 11 12 13 14 15 1) National Institute of...
متن کاملDuodenal ulcer promoting gene 1 (dupA1) is associated with A2147G clarithromycin-resistance mutation but not interleukin-8 secretion from gastric mucosa in Iraqi patients
Helicobacter pylori causes peptic ulceration and gastric adenocarcinoma. The aims were to study the influence of dupA1 positivity upon interleukin-8 (IL-8) secretion from gastric mucosa and determine the prevalence of mutations responsible for clarithromycin and fluoroquinolone resistance. DNA was extracted from 74 biopsies and the virulence factors were studied. Levels of IL-8 in gastric mucos...
متن کاملThe intact dupA cluster is a more reliable Helicobacter pylori virulence marker than dupA alone.
The duodenal ulcer promoting (dupA) gene, located in the plasticity region of Helicobacter pylori, is associated with duodenal ulcer development. dupA was predicted to form a type IV secretory system (T4SS) with vir genes around dupA (dupA cluster). We investigated the prevalence of dupA and dupA clusters and clarified associations between the dupA cluster status and clinical outcomes in the U....
متن کاملThe Helicobacter pylori duodenal ulcer promoting gene, dupA in China
BACKGROUND The prevalence of H. pylori is as high as 60-70% in Chinese population. Although duodenal ulcer and gastric cancer are both caused by H. pylori, they are at opposite ends of the spectrum and as such are considered mutually exclusive. Duodenal ulcer promoting (dupA) gene was reported to be associated with duodenal ulcer development. The aim of this study was to determine the prevalenc...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Gut Pathogens
سال: 2015
ISSN: 1757-4749
DOI: 10.1186/s13099-015-0056-2